Islet- and stem-cell-based tissue engineering in diabetes

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• 作者：Montanya ; Eduard
• 关键词：ES cell ; embryonic stem cell
• 刊名：Current Opinion in Biotechnology
• 出版年：2004
• 出版时间：October, 2004
• 年：2004
• 卷：15
• 期：5
• 页码：435-440
• 全文大小：129 K

文摘

New sources of insulin-producing cells are needed to overcome the limited availability of islet tissue for transplantation to diabetic patients. The engineering of murine or human transformed β-cell lines and of non β-cells has progressed slowly in recent years, while significant achievements have been claimed in the differentiation of insulin-producing cells from embryonic and adult stem cells. Some of the results have been questioned, however, and the generated cells lack many characteristics of differentiated β-cells. A much better understanding of the processes that govern the expansion and differentiation of stem cells is needed.