Evaluation of polymer-supported vinyltin reagents in the Stille cross-coupling reaction
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- 作者：Jean-Mathieu Chré ; tien ; Auré ; lie Mallinger ; Franç ; oise Zammattio ; Erwan Le Grognec ; Michaë ; l Paris ; Gilles Montavon ; Jean-Paul Quintard
- 关键词：Polymer-supported vinyltins ; Stille cross-coupling reaction ; Green chemistry ; β ; -Formylvinylanion
- 刊名：Tetrahedron Letters
- 出版年：2007
- 出版时间：5 March 2007
- 年：2007
- 卷：48
- 期：10
- 页码：1781-1785
- 全文大小：266 K
文摘
The synthesis of two new vinyltin reagents grafted on an insoluble macroporous polymer is reported. These reagents were used in the palladium-catalyzed Stille cross-coupling reaction with aryl halides. In all reactions, the conversion of the starting aryl halide is high and the amount of organotin by-product is particularly low (at the end of the catalytic run, the amount of Sn is up to 16 ppm in the crude reaction mixture removed of the insoluble polymer, and it is less than 1 ppm in the product purified by chromatography on silica gel).