Effectiveness of the human papillomavirus (types 6, 11, 16, and 18) vaccine in the treatment of children with recurrent respiratory papillomatosis

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• 作者：Juliana Sato Hermannp>ap>p> ; p>p>j.sato.hermann@gmail.com" class="auth_mail" title="E-mail the corresponding authorp> ; Lily Yin Weckxp>bp> ; Jussimara Monteiro Nü ; rmbergerp>cp> ; Gildo Francisco Dos Santos Juniorp>cp> ; Antonio Carlos Campos Pignatarip>dp> ; Shirley Shizue Nagata Pignatarip>ap>
• 关键词：Papilloma ; Papillomavirus vaccines ; Papillomavirus infections ; Child ; Treatment outcome
• 刊名：International Journal of Pediatric Otorhinolaryngology
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：83
• 期：Complete
• 页码：94-98
• 全文大小：260 K

文摘

To evaluate whether the quadrivalent human papillomavirus (HPV) (types 6, 11, 16, and 18) vaccine influences the clinical course of juvenile-onset recurrent respiratory papillomatosis (RRP) when administered to a group of patients with this condition.p>

Methods

<p id="spar0010">Uncontrolled intervention study of patients with juvenile-onset RRP examined at the Pediatric Otorhinolaryngology Clinic, Federal University of São Paulo, where nine patients between the ages of nine and 17 received three doses of the prophylactic quadrivalent HPV vaccine (Gardasilp>®p>) and were followed for one year. Disease staging, intervals between relapses, intervals between surgeries, and the number of surgeries during the year prior to vaccination and during the first year after vaccination were compared.p>

Results

<p id="spar0015">Eight patients were infected with HPV-6 and one with HPV-11. There were no statistically significant differences in the clinical scores (p = 0.083), anatomical scores (p = 0.257), intervals between relapses (p = 0.062), intervals between surgeries (p = 0.357), or the numbers of surgeries (p = 0.180) when the years before and after vaccination were compared. All patients had relapses following vaccination.p>

Conclusion

<p id="spar0020">Patients with juvenile-onset RRP experienced a similar clinical course in the year after versus the year before vaccination with Gardasilp>®p>.