Monitoring vascular normalization induced by antiangiogenic treatment with 18F-fluoromisonidazole-PET
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- 作者：Elena Herná ; ndez-Agudoa ; Tamara Mondejara ; Maria Luisa Soto-Montenegrob ; c ; Diego Megí ; asd ; Silvana Mourona ; Jesus Sancheza ; Manuel Hidalgoe ; Pedro Pablo Lopez-Casase ; Francisca Mulerof ; Manuel Descob ; c ; g ; Miguel Quintela-Fandinoa ; mquintela@cnio.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：Antiangiogenics ; Vascular normalization ; Biomarker ; 18F-misonidazole-PET ; Pancreatic cancer ; Breast cancer
- 刊名：Molecular Oncology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：10
- 期：5
- 页码：704-718
- 全文大小：4816 K
文摘
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We describe a new technique to monitor the efficacy of antiangiogenics.
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This drug class currently lacks biomarkers.
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Antiangiogenics exert their positive effect by inducing stromal normalization.
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18F-fluoromisonidazole PET is able to monitor stromal normalization.
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Tumors showing stromal normalization by PET experience benefit from antiangiogenics.