- 作者：Javier Martí ; nez Ollero ; javierollero@hotmail.com ; Asunció ; n Hervá ; s Moró ; n ahervas.hrc@salud.madrid.org ; Á ; ngel Montero Luis angel.monteroluis@gmail.com ; Soraya Marcos Sá ; nchez soraya8183@hotmail.com ; Andrea Abondano Nazarewsky andrea.abondano.n@gmail.com ; Ma José ; Salgueiro Ló ; pez mariajosesalgueiro@gmail.com ; Alfredo Ramos Aguerri ramosaguerri@gmail.com
- 关键词：Mucoepidermoid carcinoma ; Nasopharynx ; Salivary gland tumor ; Radiotherapy ; MEC ; Chemotherapy
- 刊名：Reports of Practical Oncology & Radiotherapy
- 出版年：2013
- 出版时间：March-April, 2013
- 年：2013
- 卷：18
- 期：2
- 页码：117-120
- 全文大小：573 K
Background
Salivary gland-type tumors originating in the nasopharynx are rare, and only a few articles about mucoepidermoid carcinomas (MEC) in this location have been reported. We describe one case of nasopharyngeal MEC and, based on a review of the literature, discuss different therapeutic approaches that can be taken regarding the result of histological findings, radiological tests and extent of disease.Case presentation
A 47-year-old woman diagnosed with mucoepidermoid carcinoma of nasopharynx, T1 N3 M0 (stage IV-B) was treated in 2007 with a combination of radiotherapy and chemotherapy to a maximum dose of 70 Gy and concomitant Cisplatin during the radiation. One year later, with the head and neck disease under control, mediastinal nodes relapse appeared which were treated with exclusive radiotherapy to a maximum dose of 65 Gy. One year after the first relapse, a second relapse was detected in the right lung, next to the previously treated mediastinal regions, and the patient initiated a treatment with exclusive chemotherapy based on TPF scheme.
Conclusion
For limited or resectable MEC, combined surgery with radiotherapy, or radiochemotherapy, should be considered the main treatment policy. On the other hand, in poorly differentiated, unresectable tumors or nasopharyngeal MEC, radiochemotherapy could be currently the main treatment approach.