Myeloablative Cord Blood Transplantation in Adults with Acute Leukemia: Comparison of Two Different Transplant Platforms

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• 作者：Jaime Sanz ; John E. Wagner ; Miguel A. Sanz ; Todd DeFor ; Pau Montesinos ; Veronika Bachanova ; Ignacio Lorenzo ; Erica Warlick ; Guillermo F. Sanz ; Claudio Brunstein
• 关键词：UCB transplantation ; Acute leukemia
• 刊名：Biology of Blood and Marrow Transplantation
• 出版年：December, 2013
• 年：2013
• 卷：19
• 期：12
• 页码：1725-1730
• 全文大小：432 K

文摘

We compared the clinical outcomes of adults with acute leukemia that received single-unit umbilical cord blood transplantation (sUCBT) after conditioning with a busulfan/antithymocyte globulin (BU-ATG)-based regimen at University Hospital La Fe (n聽= 102) or double-unit UCBT (dUCBT) after conditioning with a total body irradiation (TBI)-based regimen at the University of Minnesota (n聽= 91). Nonrelapse mortality, relapse and disease-free survival were similar in the 2 groups. Multivariate analyses, showed more rapid neutrophil (hazard ratio [HR], .6; 95% confidence interval [CI], .45 to .80; P聽= .0006) and platelet recovery (HR, .59; 95% CI, .43 to.83; P聽= .002) after the BU-ATG-based conditioning and sUCBT. Although there was a lower risk of acute graft-versus-host disease (GVHD) grade II to IV (HR, 2.81; 95% CI, 1.75 to 4.35; P < .001) after BU-ATG and sUCBT, the incidences of grade III to IV acute and chronic GVHD were similar between the 2 groups. Regarding disease-specific outcomes, disease-free survival in both acute myeloid leukemia and acute lymphoblastic leukemia (ALL) patients were not significantly different; however, a significantly lower relapse rate was found in patients with ALL treated with TBI and dUCBT (HR, .3; 95% CI, .12 to .84; P聽= .02). In the context of these specific treatment platforms, our study demonstrates that sUCB and dUCBT offer similar outcomes.