Hematopoietic Stem Cells Count and Remember Self-Renewal Divisions
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- 作者：Jeffrey M. Bernitz1 ; 2 ; 3 ; Huen Suk Kim1 ; 2 ; 3 ; Ben MacArthur4 ; 5 ; 6 ; Hans Sieburg7 ; Kateri Moore1 ; 2 ; 8 ; kateri.moore@mssm.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：hematopoietic stem cells ; aging ; dormancy ; cellular memory ; cell division counting
- 刊名：Cell
- 出版年：2016
- 出版时间：17 November 2016
- 年：2016
- 卷：167
- 期：5
- 页码：1296-1309.e10
- 全文大小：6847 K
文摘
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A rare population of dormant LR-HSCs persists throughout adult life
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Only 1% of repopulating cells within the aging HSC compartment are LT-HSCs
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LR-HSCs divide symmetrically four times throughout adult life to accumulate with age
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HSCs count and retain a memory of their cell division events in vivo