A novel injectable temperature-sensitive zinc doped chitosan/¦Â-glycerophosphate hydrogel for bone tissue engineering
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- 作者：Ramesh Niranjan<sup>1sup> ; Chandru Koushik<sup>1sup> ; Sekaran Saravanan ; Ambigapathi Moorthi ; Mariappanadar Vairamani ; Nagarajan Selvamurugan<sup> ; sup><sup>selvamn2@yahoo.comsup><sup> ; sup><sup>selvamurugan.n@ktr.srmuniv.ac.insup>
- 关键词：Hydrogel ; Zinc ; Chitosan ; Antibacterial activity ; Osteoblast differentiation
- 刊名：International Journal of Biological Macromolecules
- 出版年：2013
- 出版时间：March, 2013
- 年：2013
- 卷：54
- 期：Complete
- 页码：24-29
- 全文大小：837 K
文摘
Hydrogels are hydrophilic polymers that have a wide range of biomedical applications including bone tissue engineering. In this study we report preparation and characterization of a thermosensitive hydrogel (Zn-CS/¦Â-GP) containing zinc (Zn), chitosan (CS) and beta-glycerophosphate (¦Â-GP) for bone tissue engineering. The prepared hydrogel exhibited a liquid state at room temperature and turned into a gel at body temperature. The hydrogel was characterized by SEM, EDX, XRD, FT-IR and swelling studies. The hydrogel enhanced antibacterial activity and promoted osteoblast differentiation. Thus, we suggest that the Zn-CS/¦Â-GP hydrogel could have potential impact as an injectable in situ forming scaffold for bone tissue engineering applications.