Bioreduction of β-carboline imines to amines employing Saccharomyces bayanus

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• 作者：Marlene Espinoza-Moraga ; Tania Petta ; Marco Vasquez-Vasquez ; V. Felipe Laurie ; Luis A.B. Moraes ; Leonardo Silva Santos
• 刊名：Tetrahedron: Asymmetry
• 出版年：2010
• 出版时间：23 August 2010
• 年：2010
• 卷：21
• 期：16
• 页码：1988-1992
• 全文大小：282 K

文摘

β-Carboline imine reductions mediated by Saccharomyces bayanus have been described achieving moderate to good enantiomeric excesses of the amine products. The enantiomeric excesses of the bioreduction showed a dependence on the imine substituents. Compounds presenting C₁–C₁₁ aliphatic substituent groups afforded amines with an (S)-configuration, whereas C₁₅ and higher aliphatic- and aromatic-substituted β-carboline imines achieved inversion of the configuration in the final (R)-2 amine products. Based on this data, a model for the Saccharomyces reduction is proposed.