Development of novel cyclic peptides as pro-apoptotic agents
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- 作者：Margherita Brindisia ; b ; Samuele Maramaia ; b ; Simone Brogia ; b ; Emanuela Fanigliuloc ; Stefania Butinia ; b ; butini3@unisi.it" class="auth_mail" title="E-mail the corresponding author ; Egeria Guarinoa ; b ; Alice Casagnia ; b ; Stefania Lamponia ; b ; Claudia Bonechia ; b ; Seema M. Nathwanid ; Federica Finettib ; c ; Francesco Ragonesee ; Paola Arcidiaconoe ; Pietro Campigliaf ; Salvatore Valentia ; b ; Ettore Novellinoa ; g ; Roberta Spaccapeloe ; Lucia Morbidellib ; c ; Daniela M. Zistererd ; Clive D. Williamsd ; Alessandro Donatia ; b ; Cosima Baldaric ; Giuseppe Campiania ; b ; campiani@unisi.it" class="auth_mail" title="E-mail the corresponding author ; Cristina Ulivieric ; Sandra Gemmaa ; b
- 关键词：Pro-apoptotic agents ; Anticancer agents ; Cyclic peptides ; Peptidomimetics ; Nur77 ; Tubulin ; Bcl-2 ; NMR studies ; Molecular modeling ; Confocal microscopy ; FACS analysis
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：19 July 2016
- 年：2016
- 卷：117
- 期：Complete
- 页码：301-320
- 全文大小：3735 K
文摘
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Development of pro-apoptotic cyclic peptides and peptidomimetics
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Flow cytometry analysis on different tumor cell lines.
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Confocal microscopy and cell lysates analyses to assess cell permeability.
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Peptides and peptidomimetics conformational analysis by NMR.
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β-tubulin staining to analyze the effect of the cyclic peptides on microtubules.