Manganese(II) chloride alters behavioral and neurochemical parameters in larvae and adult zebrafish

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• 作者：Stefani Altenhofen^a ; Melissa Talita Wiprich^a ; Laura Roesler Nery^a ; Carlos Eduardo Leite^b ; Monica Ryff Moreira Roca Vianna^c ; Carla Denise Bonan^a ; ^{cbonan@pucrs.br} ; ^{carla.boli@gmail.com}
• 关键词：DOPAC ; 3 ; 4-dihydroxyphenylacetic acid ; DA ; dopamine ; Mn ; manganese ; TH ; tyrosine hydroxylase
• 刊名：Aquatic Toxicology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：182
• 期：Complete
• 页码：172-183
• 全文大小：2371 K
• 卷排序：182

文摘

MnCl2 treatment decreased exploratory behaviors in zebrafish larvae and adults. MnCl2 treatment impaired aversive long-term memory in zebrafish adults. Overall Brain TH levels were altered in adults and larvae after MnCl2 treatment. DOPAC levels were increased in adult animals exposed to MnCl2. MnCl2 exposure increased apoptotic markers, such as p53, caspase-8 and Bax-α.