Validation of the Spanish version of Addenbrooke's Cognitive Examination III for diagnosing dementia

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• 作者：J.A. Matias-Guiu^a ; ^{jordimatiasguiu@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; R. Ferná ; ndez de Bobadilla^b ; G. Escudero^a ; J. Pé ; rez-Pé ; rez^b ; A. Corté ; s^a ; E. Morenas-Rodr&iacute ; guez^b ; M. Valles-Salgado^a ; T. Moreno-Ramos^a ; J. Kulisevsky^b ; J. Mat&iacute ; as-Guiu^a
• 关键词：Cognitive screening ; Alzheimer disease ; Frontotemporal dementia ; Neuropsychological assessment ; Dementia ; Addenbrooke's Cognitive Examination
• 刊名：Neurología (English Edition)
• 出版年：2015
• 出版时间：November-December 2015
• 年：2015
• 卷：30
• 期：9
• 页码：545-551
• 全文大小：637 K

文摘

Addenbrooke's Cognitive Examination is a screening test used to diagnose dementia. The third edition of this test (ACE-III) was recently developed. The aim of this study was to translate and validate the ACE-III in Spanish.

Methods

The ACE-III was translated and adapted to Spanish. It was then administered to a group of healthy subjects as well as a group of patients with different types of mild dementia treated in 2 hospitals in Spain.

Results

Internal reliability (Cronbach's alpha = 0.927), inter-rater reliability (intraclass correlation coefficient = 0.976) and test–retest reliability (kappa 0.995) were excellent. Age (r = −0.512) and education (r = 0.659) showed a significant correlation with total test scores. The diagnostic accuracy of ACE-III was higher than that of the Mini-Mental State Examination, particularly for the group with the highest educational level. Researchers obtained normative data and cut-off points for the diagnosis of dementia.

Conclusions

The Spanish version of the ACE-III is a reliable and valid test for diagnosing dementia. Its diagnostic accuracy is high, especially in patients with a higher level of education.