The assessment of OPV vaccines by the monkey neurovirulence test: why and how to qualify the experts in histology of central nervous system

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• 作者：Poirier ; Bertrand ; Morgeaux ; Sylvie ; Fuchs ; Florence
• 关键词：OPV vaccine ; Statistics ; Monkey neurovirulence test ; Central nervous system
• 刊名：Vaccine
• 出版年：2002
• 出版时间：November 22, 2002
• 年：2002
• 卷：21
• 期：1-2
• 页码：115-119
• 全文大小：147 K

文摘

Prior to batch release of oral poliovirus vaccines (OPV) for marketing purpose, the World Health Organisation (WHO) and European pharmacopoeia require a monkey neurovirulence test to be performed both by the manufacturer and the relevant National Control Laboratory (NCL) to assess vaccine safety as regards neurovirulence.