Morin and Esculetin supplementation modulates c-myc induced energy metabolism and attenuates neoplastic changes in rats challenged with the procarcinogen 1,2 - dimethylhydrazine

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• 作者：Sharada H. Sharma^a ; Senthilkumar Thulasingam^a ; David Raj Chellappan^b ; Prabu Chinnaswamy^b ; Sangeetha Nagarajan^a ; ^{sangeetha@scbt.sastra.edu}
• 关键词：Colon cancer ; Morin ; Esculetin ; Chemoprevention ; Glycolysis ; Glutaminolysis
• 刊名：European Journal of Pharmacology
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：796
• 期：Complete
• 页码：20-31
• 全文大小：2534 K
• 卷排序：796

文摘

Morin and esculetin possess significant anti-colon cancer activity. Morin and esculetin down regulate glycolysis and glutaminolysis in colon cancer. Morin and esculetin targets β-catenin driven c-myc mediated energy metabolism. Morin exerts more pronounced effect than esculetin and morin plus esculetin.