Our study includes the analysis of both a selected sample of archeological scrapers and of experimental replicas. We were able to underline the efficiency of different types of prehension modes while isolating diagnostic wears related to each of the adopted solutions. The experiments allowed defining wears related to several handling solutions, creating a traces collection to be compared to the ones identified on the archeological sample. The results obtained so far suggest a preference towards a free hand manipulation of the scrapers, even though wear related to wrapping and also to a probable insertion of the objects in a haft have been identified as well. This work allows providing preliminary insights related to the handling solutions adopted by the human groups at Qesem Cave, underlining the overall high level of technological knowledge characterizing the Middle Pleistocene inhabitants of the site.