B cells and autoimmune liver diseases

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• 作者：Yuki Moritoki ; Zhe-Xiong Lian ; Yoshiyuki Ohsugi ; Yoshiyuki Ueno and M. Eric Gershwin
• 关键词：B cells ; Autoimmunity ; Autoantibodies ; Autoimmune hepatitis ; Primary biliary cirrhosis ; Primary sclerosing cholangitis ; Toll-like receptors
• 刊名：Autoimmunity Reviews
• 出版年：2006
• 出版时间：August 2006
• 年：2006
• 卷：5
• 期：7
• 页码：449-457
• 全文大小：973 K

文摘

Autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are the three major autoimmune diseases affecting the liver. They are all characterized by the presence of a variety of autoantibodies, some of which are found in all three diseases, whereas others are restricted to one or two of them or are even specific for the particular disease. In this review we will first provide details of the serological features of these three autoimmune diseases that target the liver. In addition, we will highlight the possible pathogenic roles of autoreactive B cells, focusing on their immunological functions as autoantibody producing cells and as antigen-presenting cells for T cell priming. As well, we will describe the contribution of toll-like receptor (TLR) signaling to the activation of autoimmune B cells and the putative role of defects in regulatory T cell function in the development of autoimmune liver diseases.