Grafting of allylimidazole and n-vinylcaprolactam as a thermosensitive polymer onto magnetic nano-particles for the extraction and determination of celecoxib in biological samples
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- 作者：Atefeh Morovati ; Homayon Ahmad Panahi ; h.ahmadpanahi@iauctb.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Farzaneh Yazdani
- 关键词：Celecoxib ; Magnetic nano-particles ; Drug delivery ; Human biological fluid
- 刊名：International Journal of Pharmaceutics
- 出版年：2016
- 出版时间：20 November 2016
- 年：2016
- 卷：513
- 期：1-2
- 页码：62-67
- 全文大小：725 K
文摘
In this research, a novel method is reported for the surface grafting of n-vinylcaprolactam as a thermosensitive agent and allylimidazole with affinity toward celecoxib onto magnetic nano-particles. The grafted nano-particles were characterized by Fourier transform infrared spectroscopy, elemental analysis, and thermogravimetric analysis. The surface morphology was studied using Scanning Electron Microscopy. The resulting grafted nano-particles were used for the determination of trace celecoxib in biological human fluids and pharmaceutical samples. The profile of celecoxib uptake by the modified magnetic nano-particles indicated good accessibility of the active sites in the grafted copolymer. It was found that the adsorption behavior could be fitted by the Langmuir adsorption isotherm model. Solid phase extraction for biological fluids such as urine and serum were investigated. In this study, urine extraction recovery of more than 95% was obtained.