Effect of circadian rhythm disturbance on morphine preference and addiction in male rats: Involvement of period genes and dopamine D1 receptor
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- 作者：B. Garmabia ; N. Vousooghia ; b ; M. Vosoughc ; A. Yoonessia ; A. Bakhtazada ; M.R. Zarrindasta ; b ; d ; e ; f ; g ; Zarinmr@ams.ac.ir" class="auth_mail" title="E-mail the corresponding author
- 关键词：CPP ; conditioned place preference ; ELISA ; enzyme-linked immunosorbent assay ; SCN ; suprachiasmatic nucleus
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：13 May 2016
- 年：2016
- 卷：322
- 期：Complete
- 页码：104-114
- 全文大小：737 K
文摘
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Constant light exposure for one month reduced the concentration of melatonin in the plasma of wistar rats.
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Constant light up-regulated the mRNA level of Per1, Per2 and dopamine D1 receptor in the striatum.
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Constant light up-regulated the mRNA level of Per2 and dopamine D1 receptor in the prefrontal cortex.
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Exposure to constant light led to greater preference for oral morphine consumption.
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Rats exposed to constant light had more severe morphine withdrawal syndrome.