HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis
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- 作者：Jacques J. Kessl1 ; 2 ; 6 ; Sebla B. Kutluay3 ; 4 ; 6 ; Dana Townsend3 ; Stephanie Rebensburg1 ; 2 ; Alison Slaughter1 ; 2 ; Ross C. Larue1 ; 2 ; Nikoloz Shkriabai1 ; 2 ; Nordine Bakouche1 ; 2 ; James R. Fuchs2 ; Paul D. Bieniasz4 ; 5 ; Mamuka Kvaratskhelia1 ; 2 ; 7 ; kvaratskhelia.1@osu.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：25 August 2016
- 年：2016
- 卷：166
- 期：5
- 页码：1257-1268.e12
- 全文大小：4571 K
文摘
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HIV-1 integrase binds viral RNA in virions
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Integrase exhibits distinct preference for select RNA structural elements
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RNA binding defective mutants of integrase yield non-infectious virions
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Allosteric integrase inhibitors impair integrase binding to viral RNA in virions