Melatonin regulates catecholamine biosynthesis by modulating bone morphogenetic protein and glucocorticoid actions

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• 作者：Motoshi Komatsubara^a ; Takayuki Hara^a ; Takeshi Hosoya^a ; Kishio Toma^a ; Naoko Tsukamoto-Yamauchi^a ; Nahoko Iwata^b ; Kenichi Inagaki^a ; Jun Wada^a ; Fumio Otsuka^b ; ^{fumiotsu@md.okayama-u.ac.jp}
• 关键词：ActRI ; activin type-I receptor ; ActRII ; activin type-II recepto ; ALK ; activin receptor-like kinase ; AR ; androgen receptor ; BMP ; bone morphogenetic protein ; BMPRI ; BMP type-I receptor ; BMPRII ; BMP type-II receptor ; DBH ; dopamine-β-hydroxylase ; DDC ; 3 ; 4-dihydroxyphenylalanine decarboxylase ; DHT ; dihydrotestosterone ; GR ; glucocorticoid receptor ; MT ; melatonin receptor ; MR ; mineralocorticoid receptor ; PKA ; protein kinase A ; PNMT ; phenylalanine N-methyltrasferase ; TGF ; transforming growth factor ; TH
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：165
• 期：part_PB
• 页码：182-189
• 全文大小：1422 K
• 卷排序：165

文摘

Melatonin suppresses catecholamine synthesis by suppressing the MT1-cAMP pathway in adrenomedullary cells. Melatonin enhances the inhibitory effect of BMP-4 on catecholamine synthesis by amplifying Smad signaling. Melatonin augments glucocorticoid-induced catecholamine synthesis by upregulating GR expression. Melatonin, BMP-4 and glucocorticoid mutually play a modulatory role in catecholamine biosynthesis.