Adenosine dialdehyde analogs I: regioselective synthesis of adenosine monoaldehydes

详细信息    查看全文

• 作者：Neenan ; John P. ; Opitz ; Sumittada M. ; Cooke ; Charles L. ; Morrill ; Terence C. ; Eckel ; Linda M. ; et. al.
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：1996
• 出版时间：June 18, 1996
• 年：1996
• 卷：6
• 期：12
• 页码：1381-1386
• 全文大小：241 K

文摘

Selective borohydride reduction of adenosine dialdehyde (1) gave the known adenosine 2′-monoaldehyde (2). Reaction of 1 with N,N′-diphenylethylenediamine, followed by reduction and deblocking gave adenosine 3′-monoaldehyde (5), a new compound. Unlike 2, compound 5 inhibited S-AdoHcy hydrolase and showed antiviral activity in vitro.