The validity of mitochondrial dehydrogenases as antimalarial drug targets

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• 作者：Akhil B. Vaidya ; Heather J. Painter ; Joanne M. Morrisey ; Michael W. Mather
• 关键词：Antimicrobial peptides ; Aureocins ; Bacteriocins ; Bovine mastitis ; Staphylococcins ; Staphylococcus aureus ; Streptococcus agalactiae
• 刊名：Trends in Parasitology
• 出版年：2008
• 出版时间：January 2008
• 年：2008
• 卷：24
• 期：1
• 页码：8-9
• 全文大小：86 K

文摘

The inhibitory activity of seven bacteriocins produced by Staphylococcus aureus (aureocins A70, A53, and 215FN) and Staphylococcus epidermidis (Pep5, epidermin, epilancin K7 and epicidin 280) was tested against strains of both S. aureus (165 strains) and Streptococcus agalactiae (74 strains) isolated from udders of cows suffering from bovine mastitis. Most strains of the two species were inhibited by epidermin (>85 % ), aureocin A53 (>67 % ) and by a combination of aureocins A70 and A53 (>91 % ), co-expressed in the genetic background of strain A70, the native producer of aureocin A70. Synergy between aureocins A70 and A53 was also demonstrated, which broadened the spectrum of strains inhibited. The remaining staphylococcins inhibited either none of, or a lower percentage (<48 % ) of, the mastitis-causing pathogens tested. Our results therefore show that the use of epidermin and/or a combination of aureocins A53 and A70 may represent a new non-antibiotic alternative for successfully inhibiting both mastitic staphylococci and streptococci.