HDAC3-Dependent Epigenetic Pathway Controls Lung Alveolar Epithelial Cell Remodeling and Spreading via miR-17-92 and TGF-β Signaling Regulation
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- 作者：Yi Wang1 ; David B. Frank2 ; Michael P. Morley1 ; Su Zhou1 ; 3 ; Xiaoru Wang8 ; Min Min Lu1 ; 3 ; Mitchell A. Lazar1 ; 4 ; Edward E. Morrisey1 ; 3 ; 5 ; 6 ; 7 ; 9 ; emorrise@mail.med.upenn.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Developmental Cell
- 出版年：2016
- 出版时间：8 February 2016
- 年：2016
- 卷：36
- 期：3
- 页码：303-315
- 全文大小：5828 K
文摘
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Hdac3 is important for AT1 cell spreading and remodeling during lung sacculation
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Hdac3 represses miR-17-92, which in turn targets components of TGF-β signaling
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Proper levels of TGF-β signaling are crucial for lung AT1 cell remodeling