Abrogation of TLR3 inhibition by discrete amino acid changes in the C-terminal half of the West Nile virus NS1 protein
详细信息 查看全文
- 作者：Clayton R. Morrison ; Frank Scholle ; frank_scholle@ncsu.edu" class="auth_mail
- 关键词：Flavivirus ; West Nile virus ; TLR3 ; NS1 ; Innate immunity
- 刊名：Virology
- 出版年：May 2014
- 年：2014
- 卷：456-457
- 期：Complete
- 页码：96-107
- 全文大小：1696 K
文摘
- •
WNV NS1 was mutated to separate its functions in replication and TLR3 inhibition.
- •
Discrete mutations in the C-terminal half of NS1 were identified.
- •
Recombinant viruses are slightly attenuated and do not inhibit TLR3.
- •
Mutated amino acids are conserved among the Flaviviridae.