A Mechanism for Somatic Brain Mosaicism

详细信息    查看全文

• 作者：Irving L. Weissman¹ ; ^{irv@stanford.edu" class="auth_mail" title="E-mail the corresponding author} ; Fred H. Gage² ; ^{gage@salk.edu" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Cell
• 出版年：2016
• 出版时间：11 February 2016
• 年：2016
• 卷：164
• 期：4
• 页码：593-595
• 全文大小：447 K

文摘

Double-strand break repair is required for neural development, and brain cells contain somatic genomic variations. Now, Wei et al. demonstrate that neural stem and progenitor cells undergo very frequent DNA breaks in a very restricted set of genes involved in neural cell adhesion and synapse function.