Adolescent mice show anxiety- and aggressive-like behavior and the reduction of long-term potentiation in mossy fiber-CA3 synapses after neonatal maternal separation
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- 作者：S.Y. Shina ; &dagger ; ; S.H. Hana ; &dagger ; ; R.-S. Woob ; S.H. Jangc ; mj@eulji.ac.kr" class="auth_mail" title="E-mail the corresponding author ; S.S. Mina ; ssmin@eulji.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACSF ; artificial cerebrospinal fluid ; EPM ; elevated plus maze ; fEPSP ; field excitatory postsynaptic potential ; FST ; forced swimming test ; HD ; handling group ; HPA ; Hypothalamic&ndash ; Pituitary&ndash ; Adrenal ; ISI ; inter-stimulus intervals ; LTP ; long-term potentiation ; MF ; mossy fiber ; MS ; maternal separation ; MWM ; Morris water maze ; PPF ; paired-pulse facilitation ; TBS ; theta burst stimulation
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：316
- 期：Complete
- 页码：221-231
- 全文大小：728 K
文摘
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Maternal separation induced anxiety and aggressive-like behavior during adolescence.
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LTP in the MF-CA3 synapse was reduced in the maternal separation group.
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PPF ratios in the MF-CA3 synapse were increased in the maternal separation group.
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An increased anxiety and aggression by early life stress may be associated with synaptic plasticity at MF-CA3 synapse.