Impact of olive oil phenolic concentration on human plasmatic phenolic metabolites

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• 作者：Laura Rubi¨® ; Rosa- M. Valls ; Alba Maci¨¤ ; Anna Pedret ; Montse Giralt ; Maria-Paz Romero ; Rafael de la Torre ; Maria-Isabel Covas ; Rosa Sol¨¤ ; Maria-Jos¨¦ Motilva
• 关键词：Bioavailability ; Dose-response ; Olive oil phenols ; Plasma phenolic metabolites
• 刊名：Food Chemistry
• 出版年：2012
• 出版时间：15 December, 2012
• 年：2012
• 卷：135
• 期：4
• 页码：2922-2929
• 全文大小：1051 K

文摘

Three different functional phenol-enriched virgin olive oils (FVOO) were prepared with a phenolic content of 250 (L-FVOO), 500 (M-FVOO), and 750 mg (H-FVOO) total phenols/kg. In a randomised, cross-over study with 12 healthy volunteers, the pharmacokinetics of phenolic biological metabolites was assessed. An increasing linear trend was observed for hydroxytyrosol sulfate, the main phenolic metabolite quantified in plasma, with C_max values of 1.35, 3.32, and 4.09 ¦Ìmol/l, and AUC mean values of 263.7, 581.4, and 724.4 ¦Ìmol/min for L-FVOO, M-FVOO, and H-FVOO, respectively. From our data an acute intake of phenol-enriched olive oils promotes a dose-dependent response of phenol conjugate metabolites in human plasma. Also, we point out for the first time hydroxytyrosol acetate sulfate as a main biological metabolite of hydroxytyrosol from olive oil ingestion.