Ugi reaction for the synthesis of 4-aminopiperidine-4-carboxylic acid derivatives. Application to the synthesis of carfentanil and remifentanil
详细信息 查看全文
- 作者：S ; ra Malaquin ; Mouhamad Jida ; Jean-Claude Gesquiere ; Rebecca Deprez-Poulain ; Benoit Deprez ; Guillaume Laconde
- 关键词：Ugi reaction ; Remifentanil ; Carfentanil ; Mumm rearrangement
- 刊名：Tetrahedron Letters
- 出版年：2010
- 出版时间：2 June 2010
- 年：2010
- 卷：51
- 期：22
- 页码：2983-2985
- 全文大小：428 K
文摘
A two-step sequence involving an Ugi four-component reaction was developed for the preparation of 4-aminopiperidine-4-carboxylic acid derivatives. This strategy has led to the successful preparation of two drugs carfentanil and remifentanil in shorter times and better yields than previously described methods.