Lambda-cyhalothrin-induced biochemical and histopathological changes in the liver of rats: Ameliorative effect of ascorbic acid

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• 作者：Hamadi Fetoui ; El Mouldi Garoui ; Najiba Zeghal
• 关键词：Lambda-cyhalothrin ; Rat ; Oxidative damage ; Antioxidant enzymes ; Vitamin C ; Liver
• 刊名：Experimental and Toxicologic Pathology
• 出版年：2009
• 出版时间：May 2009
• 年：2009
• 卷：61
• 期：3
• 页码：189-196
• 全文大小：695 K

文摘

Pyrethroid pesticides were used preferably over organochlorines and organophosphates due to their high effectiveness, low toxicity to non-target organisms and easy biodegrability. It has widespread applications in agriculture through the world and in Tunisia. The present study investigates lambda-cyhalothrin (LTC) effects on biochemical parameters, hepatotoxicity and their attenuation by vitamin C. Male Wistar rats were randomly divided into three groups of seven each: a control group (C) and two treated groups during 3 weeks with LTC administrated either alone in drinking water for LTC group or coadministred with vitamin C for LTC+vit C group. Lactate deshydrogenase (LDH) activity was significantly increased in liver (+51 % , p<0.001) and in plasma (+40 % , p<0.001) compared to those of control group. A significant increase of malondialdehyde (MDA) levels in liver (+53 % ; p<0.001) associated with a decrease in antioxidants enzyme activities and reduced glutathione (GSH) content was observed in LTC group compared to controls. The administration of vitamin C to LTC+vit C group improved all parameters studied.

We conclude that LTC induces oxidative stress and modifies biochemical parameters and histological aspects of liver. Administration of vitamin C alleviates the toxicity induced by this synthetic pyrethroid insecticide.