Acute Aspergillus pneumonia associated with mouldy tree bark-chippings, complicated by anti-glomerular basement membrane disease causing permanent renal failure

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• 作者：Louise Butler ; Tomos Brockley ; David Denning ; Malcolm Richardson ; Roger Chisholm ; Smeeta Sinha ; Ronan O鈥橠riscoll
• 关键词：Anti-glomerular basement membrane disease ; Aspergillosis ; Goodpasture's disease ; Tree bark-chippings
• 刊名：Medical Mycology Case Reports
• 出版年：2013
• 年：2013
• 卷：2
• 期：Complete
• 页码：125-127
• 全文大小：970 K

文摘

A non-immunocompromised man developed acute Aspergillus pneumonia after spreading mouldy tree bark mulch. Despite normal renal function at presentation, he developed rapidly progressive glomerulonephritis with acute kidney injury due to anti-glomerular basement membrane antibodies (anti-GBM) 4 weeks later. He remained dialysis dependent and died of sepsis 10 months later. We hypothesise that he contracted invasive pulmonary Aspergillosis from heavy exposure to fungal spores, leading to epitope exposure in the alveoli with subsequent development of GBM auto-antibodies.