Echinococcus granulosus

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• 作者：Adriana Baz ; Herná ; n Carol ; Veró ; nica Ferná ; ndez ; Gustavo Mourglia-Ettlin ; Alberto Nieto ; Anders Ö ; rn ; Sylvia Dematteis
• 刊名：Experimental Parasitology
• 出版年：2008
• 出版时间：August 2008
• 年：2008
• 卷：119
• 期：4
• 页码：460-466
• 全文大小：807 K

文摘

In this work CD4-knockout mice were used as a model to analyse the role of CD4⁺ T cells in the antibody response against Echinococcus granulosus immunization or experimental infection. Results obtained with mice immunized with protoscolex antigens indicated that these contain T-independent antigens. After infection, CD4-knockout mice and C57Bl/6 mice showed similar titres of specific antibodies indicating that T-independent antibody production was quantitatively important in early infection. We have also identified an antigenic fraction from protoscoleces (E4⁺) which induces CD4 T cell independent antibody response in early stages of infection.

In conclusion, the results presented here directly support the existence of T-independent immunogens in E. granulosus protoscoleces and suggest that T-independent antibody response may be quantitatively important in early infection.