Relationship Between Comorbidities in Patients With Cognitive Complaint and Caregiver Burden: A Cross-Sectional Study

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• 作者：Virginie Dauphinot ; PhD^a ; ^b ; ^{virginie.dauphinot@chu-lyon.fr" class="auth_mail" title="E-mail the corresponding author} ; Alix Ravier ; MD^a ; ^b ; Teddy Novais ; PharmD^a ; Floriane Delphin-Combe ; MSc^a ; Claire Moutet ; MSc^c ; Jing Xie ; MD^a ; ^c ; Christelle Mouchoux ; PharmD ; PhD^b ; ^c ; ^d ; ^e ; Pierre Krolak-Salmon ; MD ; PhD^a ; ^b ; ^c ; ^e
• 关键词：Aging ; Alzheimer disease or related disorder ; comorbidity ; Charlson Comorbidity Index ; Caregiver burden
• 刊名：Journal of the American Medical Directors Association
• 出版年：2016
• 出版时间：1 March 2016
• 年：2016
• 卷：17
• 期：3
• 页码：232-237
• 全文大小：248 K

文摘

Informal caregivers of patients with a cognitive impairment may face exhaustion while taking care of their relatives, and are themselves at higher risk of disease. The objective was to assess the relationship between patients' comorbidities evaluated with the Charlson index, and the caregiver burden, independently of health disorders related to cognitive impairment.

c_2">Design

Cross-sectional observational study.

c_3">Setting

Memory clinic at the University Hospital of Lyon.

c_4">Participants

Outpatients with cognitive complaint and consulting a Clinical and Research Memory Centre of Lyon (n = 1300).

c_5">Measurements

Comorbidity was measured using the Charlson Comorbidity Index related to age (CCI). The caregiver burden was measured with the short version of the Zarit Burden Interview (ZBI). The relationship was assessed between the CCI and the mini-Zarit and other patients' characteristics: behavior, cognition, autonomy as assessed respectively by the Neuropsychiatric Inventory (NPI), Mini Mental State Examination (MMSE), Instrumental Activities of Daily Living (IADL), etiology, and stage of the cognitive impairment.

c_6">Results

The study included 1300 outpatients: mean age: 80.8 ± 7 years. The mean CCI was 4.8 ± 1.7. The mini-Zarit score: 3.1 ± 2.0. The caregiver burden increased by 0.22 per unit of CCI (95% confidence interval 0.15–0.28, P < .001) in unadjusted analysis. The caregiver burden remained significantly associated with CCI, after adjustment for the MMSE, IADL, and NPI.

c_7">Conclusion

The caregiver burden is higher when patients' comorbidities increase, independently of behavioral and psychological symptoms, level of functional autonomy, and the stage of the cognitive disease. However, dementia may be the comorbidity that contributes the most to caregiver burden.