A bird's eye view on the use of electrospun nanofibrous scaffolds for bone tissue engineering: Current state‐of‐the‐art, emerging directions and future trends

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• 作者：Zahra Rezvani ; MSc^a ; Jayarama R. Venugopal ; PhD^b ; Aleksandra M. Urbanska ; PhD^c ; David K. Mills ; PhD^d ; Seeram Ramakrishna ; PhD^b ; ^e ; Masoud Mozafari ; PhD^a ; ^f ; ^g ; ^{mozafari.masoud@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：3D ; three-dimensional ; PVP ; poly(vinyl pyrrolidone) ; MC ; methylene chloride ; PEO ; poly(ethylene oxide) ; CaP ; calcium phosphate ; PCL ; poly-caprolactone ; PLA ; poly-lactic acid ; PLLA ; poly (L-lactic acid) ; CPC ; Calcium phosphate cement ; PLCL ; poly (lactic acid-co-caprolactone) ; bFGF ; basic fibroblast growth factor ; HCNFs ; hollow carbon nanofibers ; PAN ; poly (acrylonitrile) ; ECM ; extracellular matrix ; 2D ; two-dimensional ; DMF ; dimethylformamide ; TCD ; tip to collector distance ; HAp ; hydroxyapatite ; β
• 刊名：Nanomedicine: Nanotechnology, Biology and Medicine
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：12
• 期：7
• 页码：2181-2200
• 全文大小：2347 K

文摘

Tissue engineering aims to develop therapeutic products that utilize a combination of scaffolds with viable cell systems or responsive biomolecules derived from such cells, for the repair, restoration/regeneration of tissues. Here, the main goal is to enable the body to heal itself by the introduction of electrospun scaffolds, such that the body recognizes them as its own and in turn uses them to regenerate “neo-native” functional tissues. During the last decade, innovative nanofibrous scaffolds have attracted substantial interest in bone tissue engineering. The electrospinning process makes it possible to fabricate appropriate scaffolds for bone tissue engineering from different categories of nanobiomaterials having the ability of controlled delivery of drugs in the defective tissues. It is expected that with the progress in science and technology, better bone constructs will be proposed in the future. This review discusses the innovative approaches into electrospinning techniques for the fabrication of nanofibrous scaffolds for bone tissue engineering.