Suppressed invasive and migratory behaviors of SW1353 chondrosarcoma cells through the regulation of Src, Rac1 GTPase, and MMP13
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- 作者：Wenxiao Xua ; b ; Qiaoqiao Wana ; Sungsoo Naa ; Hiroki Yokotaa ; c ; Jing-long Yanb ; hamak@dpc.agu.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Kazunori Hamamuraa ; d ; yjl_8899@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chondrosarcoma ; eIF2α ; Src ; Rac1 ; MMP13
- 刊名：Cellular Signalling
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：27
- 期：12
- 页码：2332-2342
- 全文大小：2281 K
文摘
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Salubrinal and guanabenz suppress invasion and migration of chondrosarcoma cells.
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They do so by downregulating Src and Rac1 through eIF2α-mediated signaling.
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Salubrinal (but not guanabenz) further inhibits MMP13 through eIF2α-independent signaling.