A novel blended scaffold of polymer PLGA and designer self-assembling peptide RADA16-I-BMPH1 was designed
The peptide retained the self-assembling features and formed rod like nanostructures on top of PLGA nanofibers
PLGA-peptide scaffolds have promoted the Schwann cell bipolar extension and elongation in a significant manner
Gene expression of few neural developmental markers was significantly upregulated in the PLGA-peptide scaffolds
This combination of nanostructural & bioactive cues would enhance the axonal regeneration capacity of Schwann cells