A single genotype of Acinetobacter baumannii expresses multiple antibiotic susceptibility phenotypes

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• 作者：Timothy L. Wiemken ; PhD ; MPH ; CIC ; ^{tim.wiemken@louisville.edu" class="auth_mail} ; Daniel Curran ; MD ; Robert R. Kelley ; PhD ; Mohammad S.S. Khan ; PhD ; Ruth M. Carrico ; PhD ; RN ; FSHEA ; CIC ; Emily B. Pacholski ; MPHc ; Julio A. Ramirez ; MD ; FACP
• 关键词：Antibiotype ; Cohorting ; Outbreak ; Health care-associated infection
• 刊名：American Journal of Infection Control
• 出版年：May 2014
• 年：2014
• 卷：42
• 期：5
• 页码：556-558
• 全文大小：287 K

文摘

It is common practice to define a bacterium with unequal antibiotic susceptibility phenotypes as a different genotype. Here, we describe the utility of this practice for Acinetobacter baumannii. We determined antibiotic susceptibility for 19 clinical isolates of A baumannii. Repetitive sequence polymerase chain reaction method was used to determine genotypes. Although all isolates were of the same genotype, 79% were predicted to be different based on susceptibility patterns. The antibiotic susceptibility phenotype does not accurately predict the genotype of A baumannii.