Membrane depolarization regulates intracellular RANKL transport in non-excitable osteoblasts
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- 作者：Takuya Notomia ; b ; c ; d ; notomi@cc.osaka-dent.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Miyuki Kunod ; Akiko Hiyamaa ; Yoichi Ezurab ; Masashi Honmae ; Toru Ishizukaf ; Kiyoshi Ohuraa ; Hiromu Yawof ; Masaki Nodab ; c ; noda.mph@mri.tmd.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：PTH ; VD3 ; Osteoclast ; Voltage-gated Ca2 ; + channel ; 1 ; 25D3-MARRS receptor
- 刊名：Bone
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：81
- 期：Complete
- 页码：306-314
- 全文大小：1270 K
文摘
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Membrane depolarization is a trigger for RANKL-lv fusion to the cell membrane.
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Blue light stimulus depolarizes cell membrane in light-sensitive OB cell line.
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L-type voltage-gated Ca2 + channels are the main contributors to PTH/VD3-induced RANKLiT.
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VD3-induced RANKL-lv fusion involves a non-genomic action via membrane-bound VD3 receptor.