Generation of a Spindle Checkpoint Arrest from Synthetic Signaling Assemblies

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• 作者：Ivan Yuan¹ ; ² ; Ioanna Leontiou¹ ; ² ; Priya Amin¹ ; Karen M. May¹ ; Sadhbh Soper N&iacute ; Chafraidh¹ ; Eli&scaron ; ka Zlá ; malová ; ¹ ; Kevin G. Hardwick¹ ; ³ ; ^{kevin.hardwick@ed.ac.uk}
• 关键词：checkpoint ; spindle ; mitosis ; kinetochore ; Mad ; Bub ; Mps1 ; synthetic ; cell cycle
• 刊名：Current Biology
• 出版年：2017
• 出版时间：9 January 2017
• 年：2017
• 卷：27
• 期：1
• 页码：137-143
• 全文大小：2288 K
• 卷排序：27

文摘

Synthetic signaling scaffolds generate a spindle checkpoint arrest The combination of KNL1Spc7 and Mps1Mph1 kinase generates a robust arrest Kinetochore, spindle, and nuclear envelope enrichment of the scaffold is not required Bub3 acts to inhibit premature checkpoint activation