Blockade of IL-6 signaling by MR16-1 inhibits reduction of docosahexaenoic acid-containing phosphatidylcholine levels in a mouse model of spinal cord injury
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- 作者：H. Arimaa ; M. Hanadaa ; T. Hayasakab ; N. Masakib ; T. Omuraa ; D. Xua ; T. Hasegawaa ; D. Togawaa ; Y. Yamatoa ; S. Kobayashia ; T. Yasudaa ; Y. Matsuyamaa ; M. Setoub ; setou@hama-med.ac.jp" class="auth_mail
- 关键词：AA ; arachidonic acid ; BMS ; Basso Mouse Scale ; DHA ; docosahexaenoic acid ; DHB ; dihydroxybenzoic acid ; FA ; fatty acid ; GFAP ; glial fibrillary acidic protein ; IL ; interleukin ; IMS ; imaging mass spectrometry ; MALDI ; matrix-assisted laser desorption/ionization ; PBS ; phosphate-buffered saline ; PC ; phosphatidylcholine ; PG ; prostaglandin ; PUFA ; polyunsaturated fatty acid ; SCI ; spinal cord injury ; SPSS ; Statistical Package for the Social Sciences ; TOF ; time-of-flight
- 刊名：Neuroscience
- 出版年：6 June 2014
- 年：2014
- 卷：269
- 期：Complete
- 页码：1-10
- 全文大小：2134 K
文摘
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MR16-1 treatment suppressed the infiltration by microglia/macrophage after SCI.
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MR16-1 treatment increased locomotor function after SCI.
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MR16-1 has multiple effects on lipids in the spinal cord at 1 week after SCI.
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MR16-1 treatment influenced DHA-containing phosphatidylcholine at 1 week after SCI.