Intrathecal (i.t.) administration of BAM8-22 inhibited mechanical allodynia on day 2 post-SNL surgery.
I.t. BAM8-22 reversed microglia activation in the spinal dorsal horn.
I.t. BAM8-22 suppressed expression of nNOS in the dorsal root ganglion (DRG).
L5 SNL reduced the level of MrgC receptor mRNA in the injured L5 DRG, but not the uninjured adjacent L4 or L6 DRG, on day 2 post-SNL.
This study suggests that MrgC receptors could be targeted as a novel therapy for neuropathic pain with limited unwanted effects.