The reproductive potential of patients with Mayer-Rokitansky-Küster-Hauser syndrome using gestational surrogacy: a systematic review
详细信息 查看全文
- 作者：Shevach Friedler ; prof.friedler.s@gmail.com" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Leonti Grin ; Gad Liberti ; Buzhena Saar-Ryss ; Yaakov Rabinson ; Semion Meltzer
- 关键词：gestational surrogacy ; Mayer&ndash ; Rokitansky&ndash ; Kuster&ndash ; Hauser ; MRKH ; Mü ; llerian agenesis/aplasia
- 刊名：Reproductive BioMedicine Online
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：32
- 期：1
- 页码：54-61
- 全文大小：516 K
文摘
Women with Mayer–Rokitansky–Küster–Hauser (MRKH) syndrome may reproduce after uterine transplantation or IVF using a gestational surrogate. As uterine transplantation is still an experimental procedure, data on their clinical outcome using assisted reproduction techniques are imperative to allow evidence-based counselling. For this purpose, a systematic non-restricted electronic literature search was conducted. The 14 studies included in this review were published between 1988 and 2011. From a cohort of 140 patients with MRKH syndrome, mostly from the the USA and Israel, only four studies contained data on more than 10 patients; the others were case reports or small series. In the studies reviewed, 125 patients underwent 369 cycles of IVF with gestational surrogacy, and delivered 71 newborns. The reporting of outcome of patients with MRKH syndrome undergoing assisted reproduction techniques in the available literature is less than optimal and is characterized by bias of publication, inconsistent reports, including few patients, treated over a long time span, and lacking systematic reports from large IVF centres. None of the national registries contain specific outcome data on patients with MRKH syndrome. The paucity of data limits the possibility to draw firm conclusions but substantiates the need for a systematic multicentre reporting system.