N-linked glycans do not affect plasma membrane localization of multidrug resistance protein 4 (MRP4) but selectively alter its prostaglandin E2 transport activity
详细信息 查看全文
- 作者：M. Fahad Miaha ; b ; Gwenaë ; lle Conseilb ; Susan P.C. Colea ; b ; spc.cole@queensu.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：ABC transporter ; Membrane localization ; MRP4 ; N-glycosylation ; Polarized kidney cells ; Prostaglandin E2 transport
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：22 January 2016
- 年：2016
- 卷：469
- 期：4
- 页码：954-959
- 全文大小：926 K
文摘
- •
The ABC transporter MRP4 can localize to both apical and basolateral membranes.
- •
MRP4 is N-glycosylated only at Asn746 and Asn754.
- •
Removal of N-glycans does not affect MRP4 localization in polarized kidney cells.
- •
PGE2 transport is selectively and differentially affected by MRP4 N-glycosylation.