Down-regulation of MsrB3 induces cancer cell apoptosis through reactive oxygen species production and intrinsic mitochondrial pathway activation

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• 作者：Geun-Hee Kwak^a ; Tae-Hyoung Kim^b ; Hwa-Young Kim^a ; ^{hykim@ynu.ac.kr}
• 关键词：Methionine sulfoxide ; MsrB3 ; Redox imbalance ; Cell death ; Cancer
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：468-474
• 全文大小：1136 K
• 卷排序：483

文摘

MsrB3 deficiency induces apoptotic cancer cell death. MsrB3 depletion increases cellular ROS and redox imbalance. MsrB3 down-regulation activates the intrinsic mitochondrial apoptosis pathway.