Effects of extremely low frequency electromagnetic field and cisplatin on mRNA levels of some DNA repair genes
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- 作者：Fatemeh Sanie-Jahromi fsanie@shirazu.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Iraj Saadat isaadat@shirazu.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Mostafa Saadat ; saadat@shirazu.ac.ir" class="auth_mail" title="E-mail the corresponding author ; msaadat41@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Electromagnetic field ; Cisplatin ; NHEJ ; BER ; NER ; Gene expression
- 刊名：Life Sciences
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：166
- 期：Complete
- 页码：41-45
- 全文大小：505 K
文摘
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mRNA levels of seven genes involved in DNA repair pathways were evaluated.
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The examined genes had tendency to be down-regulated in the cells treated with EMF.
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GADD45A mRNA levels in cells co-treated with cisplatin (CDDP) + EMF were increased.
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Co-treatment of CDDP + EMF enhances down-regulation of the genes of NHEJ pathway.
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Elevation in IC50 of CDDP when cells co-treated with CDDP + EMF was observed.