Assessment of cardiovascular risk in patients with rheumatoid arthritis using the SCORE risk index

详细信息    查看全文

• 作者：Otá ; vio Augusto Martins de Campos^a ; Nazaré ; Otí ; lia Nazá ; rio^b ; Sô ; nia Cristina de Magalhã ; es Souza Fialho^c ; Guilherme Loureiro Fialho^d ; Fernando José ; Savó ; ia de Oliveira^a ; Glá ; ucio Ricardo Werner de Castro^a ; ^e ; Ivâ ; nio Alves Pereira^a ; ^e ; ^{ivanioreumato@gmail.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Rheumatoid arthritis ; Cardiovascular events ; Cardiovascular risk ; Risk factors
• 刊名：Revista Brasileira de Reumatologia (English Edition)
• 出版年：2016
• 出版时间：March-April 2016
• 年：2016
• 卷：56
• 期：2
• 页码：138-144
• 全文大小：568 K

文摘

Rheumatoid arthritis is an autoimmune disease that causes systemic involvement and is associated with increased risk of cardiovascular disease.

Objective

To analyze the prediction index of 10-year risk of a fatal cardiovascular disease event in female RA patients versus controls.

Methods

Case–control study with analysis of 100 female patients matched for age and gender versus 100 patients in the control group. For the prediction of 10-year risk of a fatal cardiovascular disease event, the SCORE and modified SCORE (mSCORE) risk indexes were used, as suggested by EULAR, in the subgroup with two or more of the following: duration of disease ≥10 years, RF and/or anti-CCP positivity, and extra-articular manifestations.

Results

The prevalence of analyzed comorbidities was similar in RA patients compared with the control group (p > 0.05). The means of the SCORE risk index in RA patients and in the control group were 1.99 (SD: 1.89) and 1.56 (SD: 1.87) (p = 0.06), respectively. The means of mSCORE index in RA patients and in the control group were 2.84 (SD = 2.86) and 1.56 (SD = 1.87) (p = 0.001), respectively. By using the SCORE risk index, 11% of RA patients were classified as of high risk, and with the use of mSCORE risk index, 36% were at high risk (p < 0.001).

Conclusion

The SCORE risk index is similar in both groups, but with the application of the mSCORE index, we recognized that RA patients have a higher 10-year risk of a fatal cardiovascular disease event, and this reinforces the importance of factors inherent to the disease not measured in the SCORE risk index, but considered in mSCORE risk index.