Regulation of the secretion of immunoregulatory factors of mesenchymal stem cells (MSCs) by collagen-based scaffolds during chondrogenesis
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- 作者：Jingyu Yang ; Xuening Chen ; xchen6@scu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Tun Yuan ; Stalight@163.com" class="auth_mail" title="E-mail the corresponding author ; Xiao Yang ; Yujiang Fan ; Xingdong Zhang
- 关键词：Immunoregulatory factors ; Mesenchymal stem cells (MSCs) ; Collagen-based scaffolds ; Cartilage tissue engineering ; Immunocompatibility
- 刊名：Materials Science & Engineering C
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：70
- 期：part_P2
- 页码：983-991
- 全文大小：1784 K
文摘
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3D collagen-based hydrogels and sponge could promote the chondrogenic differentiation of MSCs in vitro.
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In accordance with the tendency of chondrogenic differentiation, MSCs in 3D scaffolds could secrete various immunoregulatory factors.
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Scaffold structure could regulate the secretion of soluble immunoregulatory factors to inhibited the activity of allogeneic lymphocytes in a paracrine way.
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Scaffolds could modulate the immunological properties of allogeneic MSC-derived engineered tissues.