Polycyclic aromatic hydrocarbon exposure, miR-146a rs2910164 polymorphism, and heart rate variability in coke oven workers
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- 作者：Qifei Denga ; dengqf3@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Huan Guob ; Na Denga ; Wangzhen Zhangc ; Xiaohai Lib ; Huaxin Dengb ; Yongmei Xiaoa
- 关键词：PM ; particulate matter ; PAHs ; polycyclic aromatic hydrocarbons ; HRV ; heart rate variability ; miRNA ; microRNA ; SNP ; single nucleotide polymorphism ; BMI ; body mass index ; EST ; environmental tobacco smoke ; OH-PAH ; monohydroxy PAH ; LOQ ; limits of quantification ; SDNN ; standard deviation of all normal to normal NN intervals ; msec ; milliseconds ; rMSSD ; square root of the mean of squared differences of adjacent NN intervals ; LF ; low-frequency power ; VLF ; very low frequency power ; HF ; high-frequency pow
- 刊名：Environmental Research
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：148
- 期：Complete
- 页码：277-284
- 全文大小：776 K
文摘
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Rs2910164 is negatively associated with HRV in the highly PAH-exposed workers.
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PAH-exposed workers with miR-146a rs2910164 CC genotype have relatively lower HRV.
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Rs2910164 polymorphism has a modifying effect on the PAHs-HRV associations.