Snai2 and Snai3 transcriptionally regulate cellular fitness and functionality of T cell lineages through distinct gene programs
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- 作者：Peter D. Pioli1 ; pdpioli@g.ucla.edu" class="auth_mail" title="E-mail the corresponding author ; Sarah K. Whiteside ; Janis J. Weis ; John H. Weis
- 关键词：Snail transcription factors ; Autoimmunity ; Genetic deficiency ; T lymphocyte ; T cell receptor
- 刊名：Immunobiology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：221
- 期：5
- 页码：618-633
- 全文大小：4901 K
文摘
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Snai2/Snai3 regulate the competitive fitness of CD8α+, TConv and TReg cells.
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Snai2/Snai3 transcriptionally target genes essential to T cell survival and function.
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Snai2/Snai3 regulate the TReg transcriptome independent of Foxp3.