BMP1-like proteinases are essential to the structure and wound healing of skin

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• 作者：Alison M. Muir^a ; ¹ ; Dawiyat Massoudi^a ; Ngon Nguyen^b ; ^c ; Douglas R. Keene^d ; Se-Jin Lee^e ; David E. Birk^f ; Jeffrey M. Davidson^g ; ^h ; M. Peter Marinkovich^b ; ^c ; Daniel S. Greenspan^a ; ^{dsgreens@wisc.edu}
• 关键词：BMP1 ; bone morphogenetic protein 1 ; mTLL1 ; mammalian tolloid-like 1 ; OI ; osteogenesis imperfecta ; BTP ; bone morphogenetic protein 1/tolloid-like proteinase ; ECM ; extracellular matrix ; SLRP ; small leucine-rich proteoglycan ; TGFβ ; transforming growth factor β ; TEM ; transmission electron microscopy ; N-propeptide ; NH2-terminal propeptide ; C-propeptide ; COOH-terminal propeptide ; pCα1(I) ; processing intermediate that retains the C-propeptide but from which the N-propeptide has been removed ; pNα1(I) ; p
• 刊名：Matrix Biology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：56
• 期：Complete
• 页码：114-131
• 全文大小：3749 K
• 卷排序：56

文摘

Loss of BMP1-like proteinase activity results in thin skin with densely packed collagen fibrils. BMP1-like proteinases process collagens I and III, decorin, biglycan in skin. Ablation of BMP1-like proteinase activity delays wound healing in skin. Laminin 332, but not collagen VII, is processed by BMP1-like proteases during wound healing.