PDMP, a ceramide analogue, acts as an inhibitor of mTORC1 by inducing its translocation from lysosome to endoplasmic reticulum

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• 作者：Takashi Ode^a ; ^b ; Katarzyna A. Podyma-Inoue^c ; Kazue Terasawa^c ; Jin-ichi Inokuchi^d ; Toshihide Kobayashi^e ; ^f ; Tetsuro Watabe^c ; Yuichi Izumi^a ; Miki Hara-Yokoyama^c ; ^{m.yokoyama.bch@tmd.ac.jp}
• 关键词：PDMP ; mTOR ; Subcellular localization ; Lysosome ; ER ; Osteoblast
• 刊名：Experimental Cell Research
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：350
• 期：1
• 页码：103-114
• 全文大小：1918 K
• 卷排序：350

文摘

The ceramide analogue, PDMP, suppressed the activation of mTORC1. PDMP induced the translocation of mTOR from lysosomes to ER. PDMP led to the dissociation of mTOR from its activator Rheb. PDMP inhibited the mTORC1-dependent osteoblastic cell proliferation.